Related Experiment Video
Updated: Jul 27, 2025
08:32
Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels
Published on: January 28, 2022
2.4K
Flow rate resonance of actively deforming particles
Daniel R Parisi1, Lucas E Wiebke2, Judith N Mandl3
1Instituto Tecnológico de Buenos Aires (ITBA), CONICET, C.A. de Buenos Aires, Argentina. dparisi@itba.edu.ar.
Scientific Reports
|June 10, 2023
Summary
Lymphocytes avoid jamming in dense tissues by changing shape as they move. This study shows deformable, oscillating particles can flow through constrictions, unlike rigid ones, with optimal flow at resonant frequencies.
Area of Science:
- Biophysics
- Cellular dynamics
- Fluid mechanics
Background:
- Lymphoid organs feature densely packed, actively moving lymphocytes.
- The mechanism preventing jamming and clogging in these tissues is not fully understood.
- Cellular deformation during movement may play a crucial role.
Purpose of the Study:
- To investigate the role of dynamic shape changes in particle flow through constrictions.
- To model lymphocyte-like behavior in an idealized system.
- To identify conditions enabling flow in confined environments.
Main Methods:
- Numerical simulations of self-propelled, oscillating particles in 2D.
- Analysis of particle behavior in a narrow constriction.
- Varying oscillation amplitude and frequency.
Main Results:
- Deformable, oscillating particles successfully flowed through a constriction where non-deformable particles failed.
- Flow required oscillation amplitude and frequency to surpass specific thresholds.
- Maximum flow rate was observed at a resonant frequency, matching the particle's natural frequency.
Conclusions:
- Dynamic cell deformation is critical for preventing jamming in confined, active systems.
- Oscillating particle behavior offers insights into lymphocyte trafficking.
- Findings have implications for granular flow control and biological tissue dynamics.
More Related Videos
Related Concept Videos
01:14Sound Waves: Resonance
2.6K
Resonance is produced depending on the boundary conditions imposed on a wave. Resonance can be produced in a string under tension with symmetrical boundary conditions (i.e., has a node at each end). A node is defined as a fixed point where the string does not move. The symmetrical boundary conditions result in some frequencies resonating and producing standing waves, while other frequencies interfere destructively. Sound waves can resonate in a hollow tube, and the frequencies of the sound...
2.6K
01:24Rapidly Varying Flow
105
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
105
01:27Steady Flow of a Fluid Stream
316
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
316
01:10Poiseuille's Law and Reynolds Number
6.7K
Any fluid in a horizontal tube can flow due to pressure differences—fluid flows from high to low pressure. The flow rate (Q) is the ratio of pressure difference and resistance through a horizontal tube. The greater the pressure difference, the higher the flow rate. The flow resistance is expressed as:
6.7K
01:07Laminar and Turbulent Flow
8.6K
Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the...
8.6K
01:23Steady, Laminar Flow in Circular Tubes
263
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
263