Related Experiment Video

Updated: Jul 27, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.4K

The common pathobiology between coronary artery disease and calcific aortic stenosis: Evidence and clinical

Toufik Abdul-Rahman1, Ileana Lizano-Jubert2, Neil Garg3

  • 1Medical Institute, Sumy State University; Toufik's World Medical Association, Sumy, Ukraine.

Progress in Cardiovascular Diseases
|June 11, 2023
PubMed

Insights

Calcific aortic valve stenosis (CAS) and coronary artery disease (CAD) share atherosclerosis as a common mechanism. Understanding their links may improve treatments for both prevalent conditions.

Area of Science:

  • Cardiovascular Medicine
  • Pathology

Background:

  • Calcific aortic valve stenosis (CAS) is the most common valvular disease globally.
  • Coronary artery disease (CAD) is the third leading cause of death worldwide.
  • CAS and CAD frequently coexist, sharing atherosclerosis as a primary underlying mechanism.

Purpose of the Study:

  • To explore the shared pathogenesis and disparities between CAS and CAD.
  • To review the etiology and risk factors common to both diseases.
  • To discuss clinical implications and provide evidence-based management recommendations.

Main Methods:

  • Literature review of studies on CAS and CAD.
  • Analysis of shared etiological factors such as obesity, diabetes, metabolic syndrome, and lipid metabolism genes.
  • Examination of common atherosclerotic pathways.

Main Results:

  • Atherosclerosis is the central pathological process in both CAS and CAD.
  • Shared risk factors including metabolic disturbances and genetic predispositions contribute to both conditions.
  • CAS may serve as a potential marker for CAD due to their commonalities.

Conclusions:

  • Understanding the commonalities between CAS and CAD is crucial for developing integrated therapeutic strategies.
  • CAS and CAD management can benefit from addressing shared risk factors and pathological pathways.
  • Further research into the interplay between CAS and CAD can optimize patient outcomes.

Keywords:
AtherosclerosisCalcific aortic stenosisCoronary artery diseaseInflammationPathophysiologyRisk factors

More Related Videos

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.1K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.6K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
15
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
16
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
33
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
19
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
16