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The role of regulated necrosis in inflammation and ocular surface diseases

Xiao-Xiao Guo1, Qi Pu1, Jing-Jie Hu1

  • 1Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Experimental Eye Research
|June 11, 2023
PubMed

Insights

Regulated necrosis, including pyroptosis, ferroptosis, and necroptosis, drives ocular surface disease pathogenesis. Understanding these cell death types offers new prevention and treatment strategies for conditions like dry eye and keratitis.

Area of Science:

  • Cellular Biology
  • Pathology
  • Ophthalmology

Background:

  • Recent discoveries have identified various regulated cell death forms, including pyroptosis, ferroptosis, and necroptosis.
  • Regulated necrosis involves amplified inflammatory responses leading to cell death.
  • This process is implicated in the pathogenesis of ocular surface diseases.

Purpose of the Study:

  • To review the cell morphological features and molecular mechanisms of regulated necrosis.
  • To summarize the role of regulated necrosis in ocular surface diseases.
  • To identify potential disease prevention and treatment targets for ocular surface conditions.

Main Methods:

  • Literature review of regulated cell death mechanisms.
  • Analysis of cell morphology and molecular pathways.
  • Synthesis of current research on ocular surface diseases and regulated necrosis.

Main Results:

  • Regulated necrosis is characterized by specific morphological and molecular signatures.
  • These cell death pathways contribute significantly to the development of ocular surface diseases.
  • Key mechanisms underlying regulated necrosis in ocular conditions have been elucidated.

Conclusions:

  • Regulated necrosis plays a crucial role in the pathogenesis of ocular surface diseases.
  • Targeting regulated necrosis pathways presents a promising avenue for therapeutic intervention.
  • Further research into these mechanisms can lead to novel prevention and treatment strategies for dry eye, keratitis, and corneal alkali burns.
Keywords:
FerroptosisInflammationNecroptosisOcular surface diseasesPyroptosis

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