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Updated: Jul 27, 2025

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Published on: March 22, 2016
Correlated decline of cognitive and motor phenotypes and ADRD pathologies in old age
Aron S Buchman1,2, Tianhao Wang1,2, Shahram Oveisgharan1,2
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Introduction:
Examining motor and cognitive decline in separate models may underestimate their associations.
Methods:
In a single trivariate model, we examined the levels and rates of decline of three phenotypes, sensor-derived total daily physical activity, motor abilities, and cognition in 1007 older adults during 6 years of follow-up. In 477 decedents, we repeated the model adding fixed terms for indices of nine brain pathologies.
Results:
Simultaneous rates of decline of all three phenotypes showed the strongest correlations with shared variance of up to 50%. Brain pathologies explained about 3% of the variance of declining daily physical activity, 9% of declining motor abilities, and 42% of cognitive decline.
Discussion:
The rates of declining cognitive and motor phenotypes are strongly correlated and measures of brain pathologies account for only a small minority of their decline. Further work is needed to elucidate the biology underlying correlated cognitive and motor decline in aging adults.
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