Correlation of systemic immune-inflammatory response index with clinical data in patients with malignant ovarian...

To determine the correlation of the systemic immune-inflammatory response index (SIRI) with clinical data in patients with malignant ovarian tumor.

The clinical data of 118 patients with ovarian cancer (OC) treated in Ningbo Women's and Children's Hospital from February 2016 to January 2018 were retrospectively studied. Patients were divided into high and low SIRI expression groups according to the receiver operator curve (ROC) optimal cut-off (Cut-off) value, and the association of SIRI with the patient's clinical data was analyzed. Cox regression was adopted for the analysis of prognostic factors impacting the patients' 5-year survival. The associations of SIRI with tumor markers were also analyzed. A risk prediction model was constructed based on the Cox regression coefficient.

The group of patients who died showed notably higher neutrophil (NEUT) and SIRI levels than the surviving group, and also showed a significantly lower lymphocyte (LYM) level than the surviving group (P < 0.001). The areas under the ROC curves (AUC) for CA125, NEUT, LYM, and SIRI for predicting death from OC were 0.779, 0.754, 0.776, and 0.848, respectively. In addition, the AUC of each index was ranked CA125 > SIRI > LYM > NEUT. The high-expression group had a higher proportion of patients with stage III-IV and lymph node metastasis (LNM) than the low-expression group (P < 0.05). SIRI showed a positive correlation with serum carbohydrate antigen 125 (CA125), CA153, and HE4 (all P < 0.05), but had no correlation with CA199, AFP, or CEA (all P > 0.05). According to multivariate Cox regression analysis, age, FIGO stage, SIRI, and therapeutic regimen were independent prognostic factors for the 5-year survival of OC patients (all P < 0.05). The risk score was significantly higher in the death group than that in the surviving group (P < 0.001), and the AUC of this risk score for predicting 5-year survival was 0.876.

Patients with an increased SIRI level account for a large proportion of OC patients with a high FIGO stage and LNM. The 5-year survival rate of patients with a high SIRI level is unfavorable, suggesting the use of SIRI as an observation index for the prognosis of OC.