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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

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The tumor suppressor role and ceRNA network of miR-1294 in cancer

Yunan Mao1, Jinze Shen1, L I Fang2

  • 1Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, 310000, China.

Oncology Research
|June 12, 2023
PubMed

Insights

MicroRNAs (miRNAs) like miR-1294 act as tumor suppressors by regulating gene expression in cancer. Its low expression correlates with drug resistance and poor prognosis in multiple cancers, highlighting its clinical significance.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are crucial endogenous small RNA regulators of gene expression.
  • Dysregulation of miRNAs is implicated in various human diseases, particularly cancer.
  • Specific miRNAs can function as tumor suppressors or oncogenes, influencing cancer development and progression.

Purpose of the Study:

  • To investigate the role of miR-1294 in cancer.
  • To identify upstream regulators and target genes of miR-1294.
  • To explore the clinical significance of miR-1294 in various cancer types.

Main Methods:

  • Bioinformatic analysis to identify down-regulated miRNAs and their regulators.
  • Functional assays to assess the impact of miR-1294 on cancer cell behavior (proliferation, migration, invasion, apoptosis).
  • Analysis of miR-1294 target genes and their involvement in key signaling pathways.

Main Results:

  • miR-1294 was significantly down-regulated in 15 types of cancer.
  • miR-1294 influences cancer cell proliferation, migration, invasion, and apoptosis.
  • Target genes of miR-1294 are involved in PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways.
  • Six miR-1294 target genes are druggable targets.
  • Low miR-1294 expression is linked to resistance to cisplatin and TMZ, and poorer prognosis in ESCC, GC, EOC, PDAC, and NSCLC.

Conclusions:

  • miR-1294 functions as a tumor suppressor in multiple cancers.
  • The molecular mechanisms of miR-1294 involve regulation of key cancer-related signaling pathways.
  • miR-1294 holds potential as a biomarker for drug resistance and prognosis in cancer patients.
Keywords:
CancerExpressionPrognosisSignaling pathwayceRNAmiR-1294

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