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Updated: Jul 27, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

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Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by

Xufu Qin1, Ziye Jiang1, Yongcui Zhu1

  • 1Second Department of Gastroenterology, Heilongjiang Provincial Hospital, Harbin, 150001, China.

Oncology Research
|June 12, 2023
PubMed

Insights

Long noncoding RNA TMEM147-AS1 promotes gastric cancer (GC) by sponging miR-326 and upregulating SMAD5. Targeting this axis may offer new GC treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Abnormal long noncoding RNA (lncRNA) expression is linked to gastric cancer (GC) progression.
  • The specific role of TMEM147-AS1 in GC remains largely unexplored.

Purpose of the Study:

  • To investigate the expression and prognostic value of TMEM147-AS1 in GC.
  • To elucidate the functional role and molecular mechanism of TMEM147-AS1 in GC progression.

Main Methods:

  • Analysis of TMEM147-AS1 expression in GC patient data (TCGA and local cohort).
  • In vitro and in vivo experiments involving TMEM147-AS1 depletion in GC cells.
  • Investigation of the interaction between TMEM147-AS1, miR-326, and SMAD5.

Main Results:

  • TMEM147-AS1 is significantly upregulated in GC and associated with poor prognosis.
  • TMEM147-AS1 depletion inhibits GC cell proliferation, migration, invasion, and tumor growth.
  • TMEM147-AS1 acts as a molecular sponge for miR-326, leading to SMAD5 upregulation.

Conclusions:

  • TMEM147-AS1 promotes GC tumorigenesis through the TMEM147-AS1/miR-326/SMAD5 axis.
  • TMEM147-AS1 represents a potential therapeutic target for gastric cancer treatment.
Keywords:
Gastric cancerTMEM147-AS1ceRNAmiRNA sponge

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