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Immune-related adverse events of immune checkpoint inhibitors: a review

Qinan Yin1,2, Liuyun Wu1,2, Lizhu Han1,2

  • 1Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Immunology
|June 12, 2023
PubMed

Since the first Immune Checkpoint Inhibitor was developed, tumor immunotherapy has entered a new era, and the response rate and survival rate of many cancers have also been improved. Despite the success of immune checkpoint inhibitors, resistance limits the number of patients who can achieve a lasting response, and immune-related adverse events complicate treatment. The mechanism of immune-related adverse events (irAEs) is unclear. We summarize and discuss the mechanisms of action of immune checkpoint inhibitors, the different types of immune-related adverse events and their possible mechanisms, and describe possible strategies and targets for prevention and therapeutic interventions to mitigate them.

Keywords:
epidemiologyimmune checkpoint inhibitorsimmune-related adverse eventsmanagementmechanism

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