Vitamin D Toxicity Masquerading as Acute Pancreatitis

Area of Science:

• Endocrinology
• Gastroenterology
• Nephrology

Background:

• Growing interest in vitamin D supplementation due to recognized health benefits and widespread availability.
• Vitamin D deficiency remains prevalent, driving self-prescription of over-the-counter supplements.
• Potential for vitamin D toxicity is often overlooked by both patients and healthcare providers.

Observation:

• A 61-year-old male presented with symptoms indicative of acute pancreatitis.
• Laboratory results revealed elevated pancreatic enzymes, impaired renal function, and significantly high 25-hydroxyvitamin D (25-OHD) levels.
• The patient's condition was attributed to excessive vitamin D intake exceeding recommended dosages.

Findings:

• Acute pancreatitis as a direct consequence of vitamin D toxicity.
• Hypercalcemia, a common sequela of vitamin D toxicity, can precipitate pancreatitis.
• Renal dysfunction is another potential complication associated with vitamin D overdose.

Implications:

• Highlights the critical need for enhanced medical professional education regarding vitamin D toxicity.
• Emphasizes the importance of public health campaigns to inform individuals about the risks of self-medicating with high-dose vitamin D supplements.
• Underscores the necessity of monitoring vitamin D levels in patients with unexplained pancreatitis or renal dysfunction.