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Snail Immunoexpression in Endometrioid Endometrial Carcinomas
Mirela Marinela Florescu1, Oana Iulia Crețu1, Andrei Muraru1
1Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Snail protein is overexpressed in 70% of endometrial carcinomas, particularly in high-grade tumors. This suggests Snail
Area of Science:
- Gynecologic Oncology
- Cancer Biology
- Molecular Pathology
Background:
- Endometrial carcinoma is a prevalent cancer in women.
- Epithelial-mesenchymal transition (EMT) is crucial in cancer progression.
- Snail is a key transcription factor implicated in EMT.
Purpose of the Study:
- To investigate the role of Snail immunoexpression in endometrial carcinoma.
- To correlate Snail expression with tumor grade and stage.
Main Methods:
- Analysis of 30 endometrial carcinoma cases from 2020-2022.
- Immunohistochemical assessment of Snail expression in tumor cells.
- Quantification of nuclear Snail signals and correlation with tumor grade.
Main Results:
- Snail immunoexpression was detected in 70% of endometrial carcinoma cases.
- Nuclear Snail expression was quantified, averaging 38.6%±24.9% of tumor cells.
- A significant association was found between higher tumor grade and increased Snail expression (p=0.000).
Conclusions:
- Snail overexpression is common in endometrial carcinomas, especially in high-grade lesions.
- Altered epithelial-mesenchymal phenotype by Snail may drive tumor progression.
- Snail is a potential biomarker for endometrial carcinoma aggressiveness.
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