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Updated: Jul 27, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Ultrasound-Accelerated Catheter-Directed Thrombolysis
Mrhaf Alsamman1,2, Ali Mohsin Choudhry1,2, Abdulaziz Mheir AlSaadi1,2
1Department of Internal Medicine, UCF College of Medicine, Orlando, FL, USA.
Abstract:
Venous thromboembolism is a very common presentation in the hospital setting. In patients with high-risk pulmonary embolism (PE) or PE and hemodynamic instability, systemic thrombolytic treatment is generally indicated. In those with contraindications to systemic thrombolysis, catheter-directed local thrombolytic therapy and surgical embolectomy are currently considered. In particular, catheter-directed thrombolysis (CDT) is a drug delivery system coupling the endovascular drug administration nearby in the thrombus and the local facilitating effect of ultrasounds. The applications of CDT are currently debated. Here we provide a systematic review of the clinical utilization of CDT.
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