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Roles and mechanism of IL-11 in vascular diseases

Jiacheng Wu1,2,3, Wenrui Ma1,2,3,4, Zhihua Qiu1,2,3

  • 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cardiovascular Medicine
|June 12, 2023
PubMed

Insights

Interleukin-11 (IL-11) shows therapeutic potential for vascular diseases, including coronary artery disease and hypertension. Further research is needed to understand its mechanisms for improved clinical treatments.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Medical Science

Background:

  • Vascular diseases represent a major global health burden, necessitating novel therapeutic strategies.
  • Interleukin-11 (IL-11) is implicated in vascular disease development, with emerging therapeutic potential.
  • Existing knowledge on IL-11's precise role and mechanisms in vascular pathologies is limited.

Purpose of the Study:

  • To review the expression, function, and signaling pathways of IL-11.
  • To explore the role of IL-11 in various vascular diseases, including coronary artery disease, hypertension, and cerebrovascular disease.
  • To evaluate the potential of IL-11 as a therapeutic target for vascular diseases.

Main Methods:

  • Literature review and synthesis of existing research on IL-11 and vascular diseases.
  • Analysis of IL-11 expression patterns and functional roles in different vascular conditions.
  • Examination of IL-11 signaling mechanisms relevant to cardiovascular health.

Main Results:

  • IL-11 has demonstrated efficacy in treating certain vascular diseases, contrary to initial assumptions.
  • The specific functions and mechanisms of IL-11 in vascular disease pathogenesis are still under investigation.
  • IL-11 is associated with coronary artery disease, hypertension, pulmonary hypertension, cerebrovascular disease, and aortic disease.

Conclusions:

  • IL-11 presents a promising therapeutic target for a range of vascular diseases.
  • Understanding IL-11's intricate mechanisms is crucial for advancing clinical diagnosis and treatment strategies.
  • This review offers insights into IL-11's multifaceted role in vascular health and disease.

Keywords:
ERKIL-11STAT3vascular diseasesvascular smooth muscle cells

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