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Determination of Exogenous Adrenaline Levels in Patients Undergoing Cardiopulmonary Resuscitation
Mehmet Altuntaş1, Derya Bal Altuntaş2, Sema Aslan3
1Faculty of Medicine, Department of Emergency Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey.
Abstract:
Core-shell quantum dot ZnS/CdSe screen-printed electrodes were used to electrochemically measure human blood plasma levels of exogenous adrenaline administered to cardiac arrest patients. The electrochemical behavior of adrenaline on the modified electrode surface was investigated using differential pulse voltammetry (DPV), cyclic voltammetry, and electrochemical impedance spectroscopy (EIS). Under optimal conditions, the linear working ranges of the modified electrode were 0.001-3 μM (DPV) and 0.001-300 μM (EIS). The best limit of detection for this concentration range was 2.79 × 10-8 μM (DPV). The modified electrodes showed good reproducibility, stability, and sensitivity and successfully detected adrenaline levels.
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