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DNA structural variability as a factor in gene expression and evolution.

M Conrad, S K Brahmachari, V Sasisekharan

    Bio Systems
    |January 1, 1986
    PubMed
    Summary
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    Repetitive DNA acts as a buffer, stabilizing DNA structure and allowing for gradual evolutionary changes in gene regulation. This buffer structure concept offers a new perspective on repetitive DNA, exons, and introns.

    Area of Science:

    • Genomics
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • DNA sequence variations can cause structural deviations from the ideal double helix.
    • These deviations can interfere with molecular processes like DNA readout and impose evolutionary constraints.

    Purpose of the Study:

    • To explore the mechanistic and evolutionary roles of redundant DNA.
    • To introduce the 'buffer structure' concept as an interpretation for repetitive DNA elements.

    Main Methods:

    • Conceptual analysis of DNA structure and function.
    • Review of existing literature on repetitive DNA, gene regulation, and evolution.

    Main Results:

    • Redundant DNA functions as a structural buffer, mitigating sequence-dependent deviations.

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  • This buffering mechanism reduces interference with DNA readout and alleviates evolutionary energetic constraints.
  • It facilitates gradual variations in conformation-dependent gene regulation, crucial for evolutionary rates.

    • Conclusions:

    • The buffer structure concept provides a novel framework for understanding the significance of repetitive DNA.
    • This concept offers new interpretations for the roles of repetitive DNA, exons, and introns in genome evolution and function.