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Vitamin B12 induced acneiform eruption.
Imane Bahbouhi1, Maryem Aboudourib1, Ouafa Hocar1
1Department of Dermatology and Venerology, Mohammed VI University Hospital, Av. Ibn Sina 2360, Bioscience and Health Laboratory, FMPM, Cadi Ayyad University, Marrakech, Morocco.
Heliyon
|June 12, 2023
Summary
Pernicious anemia treatment with hydroxocobalamin can trigger an acneiform eruption. This rare side effect, distinct from acne vulgaris, resolved after discontinuing the vitamin B12 supplement.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Pernicious anemia requires vitamin B12 supplementation, often with hydroxocobalamin.
- Acneiform eruptions are inflammatory skin conditions that can be drug-induced.
Observation:
- A 47-year-old male developed a sudden, extensive, pruritic papulo-pustular and nodular eruption on the face and trunk.
- Comedones were present on the chest, and the eruption was monomorphic.
Findings:
- The patient was diagnosed with a vitamin B12-induced acneiform eruption.
- Discontinuation of hydroxocobalamin and initiation of lymecycline led to complete lesion resolution within 3 months.
Implications:
- This case highlights an uncommon adverse reaction to hydroxocobalamin treatment.
- Features such as age of onset, pruritus, and distribution differentiate this eruption from acne vulgaris.
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