Related Experiment Video

Updated: Jul 26, 2025

MISSION LentiPlex Pooled shRNA Library Screening in Mammalian Cells
09:12

MISSION LentiPlex Pooled shRNA Library Screening in Mammalian Cells

Published on: December 21, 2011

18.7K

Circ-SHPRH in human cancers: a systematic review and meta-analysis

Hong Xiong1, Gaozhen Huang1, Yi Zhu1

  • 1Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Frontiers in Cell and Developmental Biology
|June 12, 2023
PubMed

Insights

Circular RNA specifically circ-SHPRH plays a key role in cancer development. High circ-SHPRH expression is linked to better overall survival and lower tumor stage in cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are noncoding RNAs with unique ring-like structures.
  • Emerging evidence implicates circRNAs in tumorigenesis and cancer metastasis.
  • Circ-SHPRH, derived from the SHPRH gene, is increasingly recognized for its association with various human cancers.

Purpose of the Study:

  • To review and meta-analyze the existing literature on the role of circ-SHPRH in human cancers.
  • To elucidate the diagnostic and prognostic potential of circ-SHPRH in oncological settings.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, and Embase databases until December 24, 2022.
  • Inclusion of 18 relevant research papers, with 11 selected for meta-analysis.
  • Analysis of studies focusing on tumor diagnosis, overall survival (OS), and tumor grade.

Main Results:

  • Meta-analysis revealed that high circ-SHPRH expression correlates with better OS (HR = 0.53) and lower TNM stage (HR = 0.33).
  • Circ-SHPRH functions as a miRNA sponge or protein-encoding molecule, influencing cancer cell proliferation, invasion, and apoptosis.
  • Circ-SHPRH demonstrated significant diagnostic potential with an AUC of 0.8357.

Conclusions:

  • Circ-SHPRH plays a crucial role in the biological functions of cancer cells.
  • High circ-SHPRH expression is a favorable prognostic indicator in solid cancers.
  • Circ-SHPRH holds promise as a novel diagnostic and prognostic biomarker for human cancers.
Keywords:
Circ-SHPRHbiomarkercancercircRNAhsa_circ_0001649

More Related Videos

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.4K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
166
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K