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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
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Nanogels for bone tissue engineering - from synthesis to application.
Aravind Sankaranarayanan1, Anushikaa Ramprasad1, S Shree Ganesh1
1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur-603203, Tamil Nadu, India. selvamun@srmist.edu.in.
Nanoscale
|June 12, 2023
Summary
Nanogels, cross-linked hydrogel nanoparticles, show promise as scaffolds in bone tissue engineering. Their tunable structure supports cell adhesion, drug delivery, and enhanced bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Nanogels are hydrogel nanoparticles with tunable, porous 3D structures.
- They combine hydrogel hydration with nanoparticle properties.
- Nanogels respond to environmental changes via swelling/shrinking.
Purpose of the Study:
- To review the potential of nanogel-based scaffolds for bone tissue engineering.
- To highlight nanogels as carriers for growth factors and cells.
- To discuss their role in enhancing bone regeneration.
Main Methods:
- Review of existing literature on nanogels in bone tissue engineering.
- Analysis of nanogel properties relevant to scaffold applications.
- Examination of controlled release, mechanical support, and osteogenesis facilitation.
Main Results:
- Nanogels facilitate the transport and controlled release of therapeutic agents.
- Their 3D structure supports cell adhesion and proliferation.
- Nanogel scaffolds can enhance mechanical support and promote osteogenesis.
Conclusions:
- Nanogel-based scaffolds are promising for bone tissue engineering.
- They offer advantages in drug delivery, cell support, and bone regeneration.
- Further research into combined biomaterials may optimize nanogel constructs.
