Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.

The Biochemical journal·2026

Same author

Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulation.

bioRxiv : the preprint server for biology·2026

Same author

In vivo evidence of effective complement modulation by TriFu in comparison to C5 inhibition and complement depletion.

Blood advances·2026

Same author

A host defense role for Fibrinogen by direct binding of Clostridium botulinum C2 toxin.

Cellular and molecular life sciences : CMLS·2026

Same author

New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity.

Journal of medicinal chemistry·2026

Same author

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases.

Journal of periodontal research·2026

Search research articles

Related Experiment Video

Updated: Jul 26, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and

Xiaofei Li^1,2, Hui Wang², Christoph Q Schmidt³

¹Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Journal of Immunology (Baltimore, Md. : 1950)

|June 12, 2023

Summary

Mini-complement factor H (mini-FH) effectively treats periodontitis by reducing inflammation and bone loss. It works through both complement regulation and interaction with complement receptor 3, offering a dual therapeutic mechanism.

More Related Videos

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Related Experiment Videos

Last Updated: Jul 26, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Area of Science:

Immunology
Oral Biology
Biochemistry

Background:

Complement factor H (FH) plays a crucial role in regulating the complement system.
A modified version, mini-FH, combines regulatory and recognition domains of FH.
Previous studies showed mini-FH's efficacy in paroxysmal nocturnal hemoglobinuria models.

Purpose of the Study:

To investigate the therapeutic potential of mini-FH in periodontitis.
To elucidate the mechanisms by which mini-FH inhibits periodontitis progression.
To assess mini-FH's efficacy independently of complement regulatory activity.

Main Methods:

Utilized a ligature-induced periodontitis (LIP) mouse model.
Employed wild-type, C3-deficient, and C3/CD11b doubly deficient mice.
Administered mini-FH and a complement receptor 3-interacting FH segment (FH19-20).
Assessed periodontal inflammation and bone loss.

Main Results:

Mini-FH significantly inhibited inflammation and bone loss in wild-type mice with LIP.
Remarkably, mini-FH suppressed bone loss even in C3-deficient mice.
Inhibition of bone loss was abolished in mice lacking both C3 and CD11b.
FH19-20 also suppressed bone loss in C3-deficient mice, indicating a CD11b-dependent mechanism.

Conclusions:

Mini-FH is a promising therapeutic candidate for periodontitis.
Its efficacy extends beyond complement regulation, involving complement receptor 3 (CD11b/CD18) interaction.
Mini-FH offers a dual mechanism of action for treating periodontitis.