Related Experiment Video

Updated: Jul 26, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

8.8K

The performance of first-trimester ultrasound in diagnosing fetal cleft palate: Meta-analysis and systematic review

Dongmei Yu1, Nan Zhang1, Hui Sun2

  • 1Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China.

Journal of Clinical Ultrasound : JCU
|June 12, 2023
PubMed

Insights

First-trimester prenatal ultrasound demonstrates high accuracy in diagnosing cleft palates (CPs), with an overall detection rate of 0.874. This finding highlights its significant value in early fetal anomaly detection.

Area of Science:

  • Prenatal diagnostics
  • Fetal medicine
  • Medical imaging

Background:

  • Cleft palate (CP) is a common congenital anomaly.
  • Early diagnosis of CP is crucial for planning and management.
  • First-trimester ultrasound offers an opportunity for early detection.

Approach:

  • Systematic review and meta-analysis of 13 studies.
  • Inclusion of 39,806 fetuses.
  • Assessment of diagnostic accuracy using pooled sensitivity, specificity, and likelihood ratios.

Key Points:

  • Pooled sensitivity for CP detection was 0.874.
  • Pooled specificity was 0.999, indicating high reliability.
  • Diagnostic odds ratio (DOR) of 6651.3 and AUC of 0.9084 confirm strong diagnostic performance.

Conclusions:

  • First-trimester ultrasound is a valuable tool for diagnosing cleft palates.
  • The high accuracy supports its routine use in early prenatal screening.
  • Further research may refine ultrasound protocols for even earlier detection.
Abstract

Keywords:
cleft palatediagnostic performancefirst-trimestermeta-analysisultrasound

More Related Videos

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

50.0K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K

Related Concept Videos

Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Assessment of the Abdomen I: Inspection and Auscultation01:25

Assessment of the Abdomen I: Inspection and Auscultation

Introduction
The abdominal examination is a cornerstone of clinical medicine, serving as a critical tool in diagnosing various gastrointestinal (GI) diseases. It involves a systematic approach that includes inspection and auscultation, each with distinct yet complementary roles in assessing the abdomen. This article will delve into these two primary methods healthcare professionals use to examine the abdomen.
Inspection of the Abdomen
The first step in any abdominal examination is inspection.
Ultrasound I: Abdominal Ultrasonography01:20

Ultrasound I: Abdominal Ultrasonography

Introduction:
Abdominal ultrasonography, commonly known as abdominal ultrasound, is a vital, non-invasive medical imaging technique widely used in healthcare.
Procedure:
This diagnostic tool allows the clinician to visually inspect internal structures within the abdomen, including vital organs such as the liver, gallbladder, pancreas, kidneys, and spleen.
The abdominal ultrasound process begins with applying a special gel to the patient's skin over the abdomen. This gel enhances the...
Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...