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NETosis in Acute Thrombotic Disorders
Alessandro Bressan1, Elisabetta Faggin1, Maristella Donato2
1Department of Medicine, University of Padova, Padova, Italy.
Neutrophil extracellular traps (NETs) are elevated in acute thrombotic events. However, NETs markers do not predict future cardiovascular events or mortality in patients with acute thrombotic events.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Hematology
Background:
- Neutrophil extracellular traps (NETs) are a novel cell death mechanism implicated in thrombosis.
- NETs play a role in the pathogenesis of thrombotic disorders.
Purpose of the Study:
- To investigate NETs generation in patients with acute thrombotic events (ATEs).
- To determine if NETs markers can predict new cardiovascular events.
Main Methods:
- A case-control study included patients with acute coronary syndrome, cerebrovascular accident, and venous thromboembolism.
- Serum levels of NETs markers (e.g., MPO-DNA complexes) and neutrophil activation markers were measured.
- Follow-up assessed new cardiovascular events and mortality.
Main Results:
- Circulating myeloperoxidase (MPO)-DNA complexes were significantly increased in ATE patients versus controls.
- MPO-DNA complexes remained significant after adjusting for traditional risk factors.
- NETs markers did not influence survival or the incidence of new cardiovascular events during follow-up.
Conclusions:
- Increased NETosis markers are observed in acute arterial and venous thrombotic conditions.
- Current NETs markers measured during an ATE are not predictive of future cardiovascular risk or mortality.
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