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Updated: Jul 26, 2025
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Copper(I)-Mediated Divergent Synthesis of Pyrroquinone Derivatives and 2-Halo-3-amino-1,4-quinones
Bei Wang1,2,3, Hong Xu1,2,3, Fu-Yu Li1,2,3
1Asymmetric Synthesis and Chiraltechnology Key Laboratory of Sichuan Province, Department of Chemistry, Xihua University, Chengdu 610041, P. R. China.
Abstract:
A divergent transformation of 2-amino-1,4-quinones for the synthesis of pyrroquinone derivatives and 2-halo-3-amino-1,4-quinones was disclosed. The mechanistic study showed that both the tandem cyclization and halogenation involved a Cu(I)-catalyzed oxidative radical process. This protocol not only constructed a series of novel pyrroquinone derivatives with high atom economy but also provided a new method of halogenation via directed C(sp2)-H functionalization with CuX (X = I, Br, Cl) serving as the X (X = I, Br, Cl) source.
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