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Risk factors of left ventricular diastolic dysfunction in maintenance hemodialysis patients

Ying Lei1, JinYan Tong1, YanYan Su1

  • 1Department of Nephrology, Huadu District People's Hospitalof Guangzhou, Southern Medical University, Guangzhou, 510800, China.

BMC Nephrology
|June 12, 2023
PubMed

Insights

Age and left ventricular hypertrophy are key risk factors for left ventricular diastolic dysfunction (LVDD) in maintenance hemodialysis (MHD) patients. Early intervention is recommended to improve outcomes and reduce cardiovascular events.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Left ventricular diastolic dysfunction (LVDD) is a common complication in patients undergoing maintenance hemodialysis (MHD).
  • Identifying risk factors for LVDD is crucial for timely intervention and improved patient prognosis.

Purpose of the Study:

  • To investigate the independent risk factors associated with left ventricular diastolic dysfunction (LVDD) in patients receiving maintenance hemodialysis (MHD).

Main Methods:

  • A retrospective analysis of 363 MHD patients was conducted.
  • Patients were categorized into LVDD and non-LVDD groups based on echocardiogram results.
  • Logistic regression analysis was employed to identify significant risk factors.

Main Results:

  • Patients with LVDD were older and had a higher prevalence of coronary heart disease and symptoms like chest tightness and shortness of breath.
  • Significant cardiac structural abnormalities, including left ventricular hypertrophy and left heart enlargement, were more common in the LVDD group.
  • Advanced age (over 60 years) and left ventricular hypertrophy were identified as independent risk factors for LVDD in MHD patients.

Conclusions:

  • Age and left ventricular hypertrophy are significant risk factors for LVDD in MHD patients.
  • Early detection and intervention strategies for LVDD are recommended to mitigate cardiovascular risks in this population.
Abstract

Keywords:
Cardiac structureEchocardiographyHemodialysisLeft ventricular diastolic dysfunction

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