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Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

Aysooda Hosseinzadeh1, Faezeh Poursoleiman2, Akram Naghdipour Biregani3

  • 1Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Cancer Cell International
|June 12, 2023
PubMed

Insights

Flavonoids, natural compounds found in food, show promise in cancer therapy by inhibiting cancer cell metastasis and recurrence. This review explores how flavonoids can overcome treatment resistance and induce cancer cell death.

Area of Science:

  • Oncology
  • Natural Products Chemistry
  • Molecular Biology

Background:

  • Cancer therapy faces challenges due to inherent drug resistance and the potential for tumor recurrence and metastasis.
  • Identifying novel therapeutic agents that target all cancer cell types, including resistant ones, is crucial for improving patient outcomes.

Purpose of the Study:

  • To review the role of flavonoids as potential anti-cancer agents.
  • To explore the relationship between cancer cell metastasis, autophagy, and anoikis.
  • To present evidence for flavonoids' ability to inhibit metastasis and induce cancer cell death.

Main Methods:

  • Literature review focusing on cancer metastasis, autophagy, anoikis, and the anti-cancer effects of flavonoids.
  • Analysis of existing research demonstrating flavonoid mechanisms against cancer progression.

Main Results:

  • Flavonoids exhibit anti-cancer properties, including the inhibition of cancer cell metastasis and recurrence.
  • Flavonoids can effectively block cancer cell metastasis and induce apoptosis (programmed cell death) in cancer cells.
  • The review elucidates the complex interplay between metastasis, autophagy, and anoikis in the context of cancer therapy.

Conclusions:

  • Flavonoids represent a promising class of natural compounds for cancer therapy.
  • Their ability to target metastasis and induce cell death suggests potential in overcoming therapeutic resistance.
  • Further research into flavonoids could lead to novel strategies for comprehensive cancer treatment.
Keywords:
AnoikisAutophagyCancerDrug resistanceMetastasis

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