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Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment

Vismitha Rajeev1,2, Yuek Ling Chai1,2, Luting Poh1,2

  • 1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Acta Neuropathologica Communications
|June 12, 2023
PubMed

Insights

Chronic cerebral hypoperfusion (CCH) drives vascular cognitive impairment (VCI) by affecting brain blood flow. Understanding CCH mechanisms may lead to early detection and preventive therapies for VCI.

Area of Science:

  • Neurology
  • Neuroscience
  • Cerebrovascular Medicine

Background:

  • Vascular cognitive impairment (VCI) encompasses cognitive deficits from cerebrovascular diseases.
  • Reduced blood flow to critical brain regions is a primary cause of VCI.
  • Underlying mechanisms and disease interactions require further elucidation.

Purpose of the Study:

  • To review the pathophysiological mechanisms and neuropathological changes of chronic cerebral hypoperfusion (CCH).
  • To explore potential interventional strategies for VCI.
  • To highlight the importance of understanding CCH for VCI management.

Main Methods:

  • Review of recent clinical studies on cerebral blood flow measurements.
  • Analysis of pathophysiological and neuropathological data related to CCH.
  • Synthesis of current knowledge on VCI mechanisms and interventions.

Main Results:

  • Chronic cerebral hypoperfusion (CCH) is identified as a major driver of VCI pathology and clinical symptoms.
  • CCH contributes to the accumulation of VCI-associated neuropathology.
  • Current understanding points to CCH as a critical factor in VCI development.

Conclusions:

  • A comprehensive understanding of CCH is crucial for advancing VCI research.
  • Targeting CCH could enable early detection and disease-modifying therapies for VCI.
  • Focusing on CCH may shift VCI treatment from symptomatic to preventive interventions.

Keywords:
Chronic cerebral hypoperfusionNeuronal cell deathVascular dementiaWhite matter lesions

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