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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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Hematological Oncology journal women in lymphoma special issue: Latest updates in nodal peripheral T-cell lymphoma
Limei Poon1, Laurence de Leval2, Siok Bian Ng3
1Department of Hematology/Oncology, National University Cancer Institute, Singapore, Singapore.
Abstract:
In the last decade, there has been increased understanding of the pathologic features and biology of peripheral T cell lymphomas (PTCLs) through development of multi omics and molecular profiling techniques. In addition, international collaborations through multi center trials as well as prospective registry studies have improved our knowledge of host and tumor genomic factors and treatment factors affecting disease outcomes. In our review today, we aim to highlight the current epidemiology, latest advances in classification, disease biology and the evolving treatment landscape for nodal PTCLs.
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