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An overview of opportunistic fungal infections associated with COVID-19

Navidita Kangabam1, V Nethravathy1

  • 1, Rukmini Knowledge Park, Kattigenehalli, Yelahanka, Bengaluru, 560064 India Department of Biotechnology, School of Applied Sciences, REVA University.

3 Biotech
|June 13, 2023
PubMed

Insights

COVID-19 survivors face fungal co-infections like candidiasis, aspergillosis, and mucormycosis. Early diagnosis and treatment are crucial for recovery and reducing fatalities from these opportunistic infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • COVID-19 Research

Background:

  • COVID-19 survivors and patients on long-term steroids are susceptible to opportunistic fungal co-infections.
  • Fungal species including *Candida*, *Aspergillus*, and *Mucor* genera cause significant morbidity in these patients.
  • Reported cases include mucormycosis, aspergillosis, and candidiasis, complicating COVID-19 recovery.

Purpose of the Study:

  • To review systemic and superficial opportunistic fungal infections in COVID-19 survivors.
  • To summarize the incidence, pathogenicity, and treatment of these fungal co-infections.
  • To highlight the need for advanced diagnostic techniques for early detection and mortality reduction.

Main Methods:

  • Literature review of opportunistic fungal infections in COVID-19 survivors.
  • Analysis of reported cases, incidence, and pathogenicity.
  • Compilation of current and emerging treatment strategies.

Main Results:

  • Identified *Candida*, *Aspergillus*, and *Mucor* as key fungal pathogens.
  • Detailed common fungal infections such as mucormycosis, aspergillosis, and candidiasis.
  • Summarized various treatment modalities including polyenes, azoles, echinocandins, and immunomodulatory therapies.

Conclusions:

  • Prompt diagnosis and effective treatment are essential for managing fungal co-infections in COVID-19 survivors.
  • Advanced diagnostic tools are necessary for early identification and improved patient outcomes.
  • Understanding the spectrum of these infections is critical for reducing mortality and improving recovery rates.
Keywords:
AzolesDiabetesOpportunistic fungal infectionsPolyenesPost-COVID-19

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