Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022

Area of Science:

• Pharmacokinetics and Drug Metabolism
• Medicinal Chemistry
• Biotechnology

Background:

• Peptides and oligonucleotides represent promising therapeutic modalities.
• Significant challenges exist in understanding and optimizing their absorption, distribution, metabolism, and elimination (ADME).
• The Drug Metabolism and Discussion Group (DMDG) convened a workshop to address these issues.

Purpose of the Study:

• To summarize key discussions and insights from the DMDG Peptide and Oligonucleotide ADME Workshop 2022.
• To highlight current challenges and proposed solutions in peptide and oligonucleotide ADME.
• To provide an overview of the topics covered, including drug modality landscape, metabolism, analytical methods, drug-drug interactions, and regulatory considerations.

Main Methods:

• The report is based on presentations and discussions from the DMDG workshop.
• Key topics were synthesized from expert contributions.
• Industry working group reports were incorporated.

Main Results:

• The workshop covered the current drug modality landscape for peptides and oligonucleotides.
• Discussions addressed metabolism and modeling strategies.
• Analytical challenges and drug-drug interaction reports were presented.
• Regulatory interactions concerning these drug classes were explored.

Conclusions:

• Addressing ADME challenges is crucial for the successful development of peptide and oligonucleotide therapeutics.
• Collaboration and discussion among experts are vital for advancing the field.
• The workshop provided valuable insights into overcoming hurdles in peptide and oligonucleotide drug development.