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IRE1α: from the function to the potential therapeutic target in atherosclerosis

Zheng-Yang Zhou1,2, Li Wu1,2, Yi-Fan Liu1

  • 1The Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, People's Republic of China.

Molecular and Cellular Biochemistry
|June 13, 2023
PubMed
Summary

Inositol requiring enzyme 1-alpha (IRE1α) is linked to inflammation and lipid imbalance, driving atherosclerosis progression. Targeting IRE1α may offer new therapeutic strategies for cardiovascular disease prevention.

Keywords:
AtherosclerosisEndoplasmic reticulum stressIRE1αX-box binding protein 1

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