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Combating polymicrobial biofilm: recent approaches

Anmol Kulshrestha1, Pratima Gupta2

  • 1Department of Biotechnology, National Institute of Technology, Raipur, India.

Folia Microbiologica
|June 13, 2023
PubMed

Insights

Polymicrobial biofilms (PMBF) are challenging to treat due to drug-resistant microbes. This study explores antibiofilm compounds that target cell adhesion, cell walls, or quorum sensing to combat these infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Polymicrobial biofilms (PMBF) involve multiple species co-aggregating within an extracellular polymeric substance (EPS) matrix.
  • PMBF formation is associated with persistent human infections like cystic fibrosis, dental caries, and urinary tract infections.
  • The multi-species nature of PMBF often confers resistance to conventional antibiotics and antifungals, posing significant therapeutic challenges.

Purpose of the Study:

  • To review and discuss the mechanisms of action for various antibiofilm compounds.
  • To highlight strategies for combating drug-resistant polymicrobial infections.

Main Methods:

  • Literature review of antibiofilm compound mechanisms.
  • Categorization of compounds based on their mode of action.

Main Results:

  • Antimicrobial compounds function through diverse mechanisms.
  • Key targets include blocking microbial cell-to-cell adhesion.
  • Other mechanisms involve altering microbial cell membranes/walls or disrupting intercellular communication via quorum-sensing systems.

Conclusions:

  • Understanding these diverse antibiofilm mechanisms is crucial for developing novel therapeutic strategies.
  • Targeting specific pathways in PMBF offers potential for overcoming drug resistance.
Keywords:
Antibiofilm compoundsAntimicrobial resistanceCell adhesionPolymicrobial biofilm

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