Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

60
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
60
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

144
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
144

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homovanillic acid inhibits Candida albicans-Staphylococcus aureus polymicrobial biofilm: in vitro and in vivo evaluation.

Journal of applied microbiology·2026
Same author

A next-generation SPE-enabled microfluidic device for the rapid screening of antibiofilm compounds.

Journal of microbiological methods·2026
Same author

Control of <i>Candida albicans</i> and <i>Staphylococcus aureus</i> dual species interkingdom biofilm development via SAP5 inhibition.

Future microbiology·2025
Same author

Multi-computational screening identifies homovanillic acid as a potential SAP5 inhibitor against Candida albicans biofilms.

Computational biology and chemistry·2025
Same author

Real-time biofilm detection techniques: advances and applications.

Future microbiology·2024
Same author

Secreted aspartyl proteases family: a perspective review on the regulation of fungal pathogenesis.

Future microbiology·2023
Same journal

Molecular epidemiology and clinical course of PVL-positive MRSA CC398 infections.

Folia microbiologica·2026
Same journal

Proline treatment improves salinity tolerance in the green microalga Dunaliella sp. by altering carbon partitioning and inducing metabolites accumulation.

Folia microbiologica·2026
Same journal

Czechoslovak/Prague School of Immunology.

Folia microbiologica·2026
Same journal

Anti-Candida albicans and anti-virulence activities of vaginal Lactobacillus strains from asymptomatic women: phenotypic characterization and prediction of antimicrobial peptide gene clusters.

Folia microbiologica·2026
Same journal

The integrative role of the microbiome in systemic immuno-inflammatory aberrations.

Folia microbiologica·2026
Same journal

Gnotobiology: from 19th-century global foundations to 21st-century omics - six decades of Czech contribution to microbiome research.

Folia microbiologica·2026
See all related articles

Related Experiment Video

Updated: Jul 26, 2025

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

17.8K

Combating polymicrobial biofilm: recent approaches.

Anmol Kulshrestha1, Pratima Gupta2

  • 1Department of Biotechnology, National Institute of Technology, Raipur, India.

Folia Microbiologica
|June 13, 2023
PubMed
Summary
This summary is machine-generated.

Polymicrobial biofilms (PMBF) are challenging to treat due to drug-resistant microbes. This study explores antibiofilm compounds that target cell adhesion, cell walls, or quorum sensing to combat these infections.

Keywords:
Antibiofilm compoundsAntimicrobial resistanceCell adhesionPolymicrobial biofilm

More Related Videos

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

1.1K
Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

7.7K

Related Experiment Videos

Last Updated: Jul 26, 2025

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

17.8K
Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

1.1K
Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

7.7K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Polymicrobial biofilms (PMBF) involve multiple species co-aggregating within an extracellular polymeric substance (EPS) matrix.
  • PMBF formation is associated with persistent human infections like cystic fibrosis, dental caries, and urinary tract infections.
  • The multi-species nature of PMBF often confers resistance to conventional antibiotics and antifungals, posing significant therapeutic challenges.

Purpose of the Study:

  • To review and discuss the mechanisms of action for various antibiofilm compounds.
  • To highlight strategies for combating drug-resistant polymicrobial infections.

Main Methods:

  • Literature review of antibiofilm compound mechanisms.
  • Categorization of compounds based on their mode of action.

Main Results:

  • Antimicrobial compounds function through diverse mechanisms.
  • Key targets include blocking microbial cell-to-cell adhesion.
  • Other mechanisms involve altering microbial cell membranes/walls or disrupting intercellular communication via quorum-sensing systems.

Conclusions:

  • Understanding these diverse antibiofilm mechanisms is crucial for developing novel therapeutic strategies.
  • Targeting specific pathways in PMBF offers potential for overcoming drug resistance.