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Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers

Maryam Farzaneh1, Mahrokh Abouali Gale Dari2, Amir Anbiyaiee3

  • 1Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Journal of Cell Communication and Signaling
|June 13, 2023
PubMed

Insights

Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is crucial in gynecologic cancers. NEAT1 shows potential as a biomarker for predicting and treating breast, ovarian, cervical, and endometrial cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gynecologic cancers pose a significant global health challenge for women.
  • Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer development and progression.
  • Nuclear paraspeckle assembly transcript 1 (NEAT1) is a lncRNA implicated in various cellular processes relevant to cancer.

Purpose of the Study:

  • To review the role of NEAT1 in gynecologic cancers.
  • To summarize NEAT1-related signaling pathways critical in gynecologic cancer progression.
  • To explore NEAT1 as a potential biomarker for gynecologic cancer diagnosis and treatment.

Main Methods:

  • This study is a narrative review.
  • Literature search on NEAT1 and gynecologic cancers.
  • Analysis of NEAT1's involvement in tumorigenesis and progression via miRNA/mRNA axes.

Main Results:

  • NEAT1 mediates cell proliferation, migration, and epithelial-mesenchymal transition (EMT) in gynecologic cancers.
  • NEAT1 targets multiple miRNA/mRNA pathways crucial for cancer development.
  • NEAT1 is implicated in breast, ovarian, cervical, and endometrial cancers.

Conclusions:

  • NEAT1 plays a pivotal role in the tumorigenesis and progression of gynecologic cancers.
  • NEAT1 holds promise as a potent biomarker for the prediction and treatment of these cancers.
  • Targeting NEAT1-related pathways may offer novel therapeutic strategies for gynecologic malignancies.
Keywords:
BiomarkerGynecologic cancerLncRNAsNEAT1Tumorigenesis

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