Incidence and Risk Factors for Antibiotic-associated Diarrhea Among Hospitalized Children.
Gülay Kaya1, Deniz Usta1, Elif Sag2
1From the Division of Pediatrics, Karadeniz Technical University, Trabzon, Turkey.
The Pediatric Infectious Disease Journal
|June 13, 2023
Summary
Antibiotic-associated diarrhea (AAD) is uncommon in hospitalized children without other health issues, with most cases being mild. Risk factors include male sex, young age, ibuprofen use, and delayed antibiotic administration.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Antibiotic-associated diarrhea (AAD) is a common concern in pediatric healthcare.
- Understanding AAD incidence and risk factors in healthy hospitalized children is crucial for effective management.
Purpose of the Study:
- To determine the incidence, clinical characteristics, and risk factors of AAD.
- To investigate AAD in hospitalized pediatric patients without pre-existing comorbid conditions.
Main Methods:
- A prospective study included 358 hospitalized children over one year.
- AAD was defined by specific stool criteria during antibiotic therapy.
- Exclusion of known infectious causes and comorbid diseases was applied.
Main Results:
- The overall incidence of AAD was 6.14% (22/358 patients).
- Identified risk factors included male sex, age 1 month to <3 years, ibuprofen use, and delayed antibiotic administration.
- Only one case tested positive for Clostridioides difficile toxin B.
Conclusions:
- AAD incidence is low in hospitalized children without comorbidities and typically mild.
- Probiotic use may be indicated only in specific situations for this patient group.
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