Transformative Materials to Create 3D Functional Human Tissue Models In Vitro in a Reproducible Manner.

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Tissue Engineering

Background:

• In vitro tissue models are essential tools for understanding human physiology and disease.
• Transformative materials are key to directing cell behavior and improving drug development.
• Nature-inspired biomaterials mimic organogenesis and tissue regeneration processes.

Purpose of the Study:

• To present state-of-the-art developments in in vitro tissue engineering.
• To discuss challenges in designing, producing, and translating transformative materials.
• To highlight the convergence of technologies for creating functional human tissue models.

Main Methods:

• Utilizing advances in (stem) cell sources, expansion, and differentiation.
• Incorporating novel responsive materials and automated fabrication processes.
• Employing advanced culture conditions, in situ monitoring, and computer simulations.

Main Results:

• Development of sophisticated in vitro models for physiological and disease studies.
• Demonstration of transformative materials programming cell behavior.
• Integration of diverse technologies to create life-like tissue models.

Conclusions:

• Convergent technologies are essential for generating functional in vitro human tissue models.
• These models offer a powerful platform for drug discovery and validation.
• Continued innovation in materials and fabrication is crucial for advancing biomedical science.