Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Cancer Vaccines01:30

Cancer Vaccines

434
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
434
Regulated mRNA Transport02:22

Regulated mRNA Transport

6.3K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of the role of inflammation-linked signaling pathways in ventilator-induced diaphragmatic dysfunction in rats by transcriptome RNA-seq.

BMC molecular and cell biology·2026
Same author

mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cimibiosides A-C: Three 9,10-seco triterpenoid glycosides isolated from Cimicifuga foetida L.

Fitoterapia·2026
Same author

Thermoresponsive Nanoparticles Hijack Neutrophils In Vivo to In Situ Construct Biohybrids for Enhanced Cancer and Infection Therapy.

ACS nano·2026
Same author

In vitro fertilization-frozen embryo transfer in a patient with gonadotroph adenoma: Exacerbation of ovarian hyperstimulation by triptorelin: a case report.

Journal of medical case reports·2026
Same author

A New Sulfated Cholestane From the Sea Urchin Mesocentrotus nudus With Cytotoxic Activity.

Chemistry & biodiversity·2026

Related Experiment Video

Updated: Jul 26, 2025

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

405

mRNA-based cancer therapeutics.

Chuang Liu1, Qiangqiang Shi1,2, Xiangang Huang1

  • 1Center for Nanomedicine and Department of Anaesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Nature Reviews. Cancer
|June 13, 2023
PubMed
Summary

Messenger RNA (mRNA) therapeutics offer a faster, cheaper way to create diverse cancer treatments. This technology is becoming a cornerstone of cancer drug development, with many promising therapies advancing to clinical trials.

More Related Videos

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

3.7K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Related Experiment Videos

Last Updated: Jul 26, 2025

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

405
A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

3.7K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Area of Science:

  • Oncology
  • Biotechnology
  • Molecular Medicine

Background:

  • Messenger RNA (mRNA) technology enables rapid and cost-effective production of diverse vaccines and therapeutics.
  • Recent advancements have led to a surge in mRNA-based therapeutic development for various applications.
  • Clinically approved mRNA vaccines demonstrate the safety and efficacy of this platform.

Purpose of the Study:

  • To review *in vitro* transcribed mRNA-based therapeutics for cancer treatment.
  • To discuss the characteristics of synthetic mRNA, delivery systems, and clinical progress.
  • To explore current challenges and future prospects of mRNA technology in oncology.

Main Methods:

  • Review of preclinical and clinical studies on mRNA-based cancer therapeutics.
  • Analysis of synthetic mRNA types and their packaging systems for efficient delivery.
  • Examination of therapeutic strategies including cancer vaccines, immunotherapy, and gene therapy.

Main Results:

  • Numerous mRNA therapeutics targeting cancer antigens, cytokines, tumor suppressors, and gene-editing proteins show promising preclinical efficacy.
  • Several mRNA-based cancer therapies have progressed into clinical trials.
  • The established success of mRNA vaccines supports the potential of mRNA therapeutics.

Conclusions:

  • mRNA technology is a rapidly growing field with significant potential in cancer drug development.
  • Continued research and clinical translation are expected to yield novel mRNA-based cancer treatments.
  • mRNA therapeutics are poised to become a major pillar in the future of cancer care.