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Related Experiment Video

Updated: Jul 26, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Local Antibiogram Predicts Appropriate Antibiotic Selection for Prostate Biopsy Prophylaxis.

Elizabeth Rourke1, Steven Madsen1, Andrea Yunes1

  • 1University of Texas Health San Antonio and South Texas Veterans Health Care, San Antonio, Texas.

Urology Practice
|June 14, 2023
PubMed
Summary
This summary is machine-generated.

A local antibiogram accurately reflects fluoroquinolone resistance in Escherichia coli, supporting its use for targeted antibiotic selection before prostate biopsies. This improves antibiotic stewardship and patient outcomes.

Keywords:
biopsydrug resistancefluoroquinolonesmicrobial sensitivity testsneedleprostate

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Area of Science:

  • Infectious Diseases
  • Urology
  • Clinical Microbiology

Background:

  • Transrectal prostate biopsy carries a risk of infectious complications.
  • Antibiotic prophylaxis is standard, but rising resistance necessitates accurate local antibiograms.
  • Evaluating local resistance patterns ensures effective antibiotic augmentation.

Purpose of the Study:

  • To assess the accuracy of the South Texas Veterans Health Care System (STVHCS) local antibiogram.
  • To determine if the antibiogram reflects resistance patterns in fluoroquinolone-resistant Escherichia coli.
  • To validate the antibiogram's utility for guiding antibiotic prophylaxis before transrectal prostate biopsy.

Main Methods:

  • Retrospective analysis of rectal swab cultures from patients undergoing transrectal prostate biopsy (January 2016 - September 2017).
  • Identification of ciprofloxacin-resistant Escherichia coli isolates.
  • Comparison of observed resistance profiles with the 2016 STVHCS antibiogram data.

Main Results:

  • 80% sensitivity to ciprofloxacin in the cohort versus 65% in the STVHCS antibiogram (p <0.001).
  • Similar sensitivities for gentamicin between the cohort (88%) and antibiogram (90%).
  • Significant difference in ampicillin/sulbactam sensitivity (32% vs. 57%, p=0.019); 4% of ciprofloxacin-resistant E. coli were ESBL producers.

Conclusions:

  • Local antibiogram resistance patterns for ciprofloxacin-resistant E. coli are largely consistent with the STVHCS antibiogram.
  • A local antibiogram is a reliable tool for implementing targeted antibiotic strategies.
  • This supports using local antibiograms to augment fluoroquinolone prophylaxis for transrectal prostate biopsies.