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Orbital lymphocyte populations in three states of thyroid eye disease
Shane M Griffin1, Rona Z Silkiss1,2
1California Pacific Medical Center (CPMC), 711 Van Ness Ave, San Francisco, CA, USA.
Purpose:
We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) - active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED.
Observations:
Orbital tissues in TED demonstrate minimal lymphocytic infiltration in fat and Mueller's muscle. Following teprotumumab treatment, the tissues were devoid of lymphocytes with only perivascular cuffs of T-lymphocytes remaining in orbital fat.
Conclusions And Importance:
In active TED, post-teprotumumab treatment, and in quiescent TED, orbital fat may not show significant inflammatory infiltration. More work is warranted to characterize specific cellular effects of teprotumumab and other biologics.
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