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mRNA expression of caspase 14 in skin epithelial malignancies

Agnieszka Markiewicz1, Dawid Sigorski2, Mateusz Markiewicz3

  • 1Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland.

Postepy Dermatologii I Alergologii
|June 14, 2023
PubMed
Abstract

Insights

Caspase 14 mRNA expression is lower in non-lesional skin of patients with skin cancer, suggesting its prognostic potential for identifying individuals predisposed to basal cell cancer and squamous cell cancer.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Oncology

Background:

  • Skin epithelial cancers are common human neoplasms.
  • Dysregulation of cell proliferation and death contributes to skin malignancies.
  • Caspase 14, a unique caspase, does not participate in apoptosis, and its role in skin cancer is unclear.

Purpose of the Study:

  • To analyze the mRNA expression of caspase 14 in skin epithelial malignancies.
  • To investigate the potential prognostic value of caspase 14 mRNA in skin cancer predisposition.

Main Methods:

  • Prospective study involving 56 patients (21 controls, 35 study group).
  • Analysis of caspase 14 mRNA expression in lesional and non-lesional skin samples.
  • Comparison of expression levels between cancer patients and controls.

Main Results:

  • Caspase 14 mRNA expression was lower in non-lesional skin of basal cell cancer (BCC) or squamous cell cancer (SCC) patients compared to controls.
  • Expression levels were also lower in non-lesional skin from BCC/SCC patients versus their lesional samples.

Conclusions:

  • Caspase 14 mRNA may have prognostic potential for identifying patients at risk of skin cancer.
  • Further research is needed to fully elucidate the role of caspase 14 in skin epithelial malignancies.
Keywords:
basal cell cancercaspase 14skin cancersquamous cell cancer

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