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Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory

Shigeru Yokoyama^1,2

¹Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.

Frontiers in Immunology

|June 14, 2023

Abstract:

Bone marrow stromal cell antigen-1 (BST-1/CD157) is an immune/inflammatory regulator that functions as both nicotinamide adenine dinucleotide-metabolizing ectoenzyme and cell-surface signaling receptor. BST-1/CD157 is expressed not only in peripheral tissues, but in the central nervous system (CNS). Although its pathophysiological significance in the CNS is still unclear, clinical genetic studies over a decade have begun revealing relationships between BST-1/CD157 and neuropsychiatric diseases including Parkinson's disease, autism spectrum disorders, sleep disorders, depressive disorders and restless leg syndrome. This review summarizes the accumulating evidence for the involvement of BST-1/CD157 in these disorders.

Keywords:

BST-1 CD157 Parkinson’s disease anxiety autism spectrum disorder neuroimmune dysfunction single-nucleotide polymorphism

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