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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jun 18, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Nanocellulose-based hydrogels for drug delivery.

Yusen Ai1, Zhongxin Lin1, Wenqi Zhao2

  • 1State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.

Journal of Materials Chemistry. B
|June 14, 2023
PubMed
Summary

Nanocellulose hydrogels offer promising drug delivery systems (DDSs) due to their biocompatibility and tunable properties. This review details their preparation, forms, and performance for advanced DDS applications.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Hydrogels are crucial 3D polymer networks for drug delivery systems (DDSs) due to porosity and hydrophilicity.
  • Clinical DDS requirements include low toxicity, high biocompatibility, targeting, controlled release, and high drug loading.
  • Nanocellulose, including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs), is a promising biomaterial for hydrogel-based DDSs.

Purpose of the Study:

  • To provide a comprehensive review of nanocellulose-based hydrogels for drug delivery.
  • To discuss preparation methods, carrier forms, and drug delivery parameters.
  • To identify opportunities, challenges, and future research directions for these advanced DDS.

Main Methods:

  • Review of physical and chemical crosslinking methods for nanocellulose hydrogel preparation.
  • Analysis of various nanocellulose hydrogel carrier forms (particles, films, injectable, sprayable).
  • Examination of drug loading efficiency, release kinetics, and stimuli-responsiveness.

Main Results:

  • Nanocellulose hydrogels offer high surface area, biocompatibility, and degradability for DDS.
  • Diverse preparation techniques enable tailored hydrogel properties for specific drug delivery needs.
  • Nanocellulose hydrogels demonstrate potential for efficient drug loading and controlled release.

Conclusions:

  • Nanocellulose-based hydrogels represent a versatile platform for advanced drug delivery systems.
  • Further research into applications, challenges, and optimization is needed to fully realize their potential.
  • Future directions include multifunctionalization and exploration of novel DDS formulations.