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MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer

Jian Lei1,2, Jing-Ying Xu1, Min Hu1

  • 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.

Discover Oncology
|June 14, 2023
PubMed
Abstract

Insights

MOB Kinase Activator 1A (MOB1A) is highly expressed in ovarian cancer (OC), promoting tumor growth and poor survival. Inhibiting MOB1A suppresses OC cell malignancy via the PI3K/AKT/mTOR pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Ovarian cancer (OC) remains a significant health challenge with complex underlying mechanisms.
  • Understanding the role of specific genes like MOB Kinase Activator 1A (MOB1A) is crucial for developing targeted therapies.

Purpose of the Study:

  • To elucidate the specific functions and implications of MOB1A in the pathogenesis and progression of ovarian cancer.
  • To investigate the molecular pathways influenced by MOB1A in OC development.

Main Methods:

  • Utilized public databases (gene expression, proteomics) and validation in OC cell lines and datasets.
  • Employed RNA interference and lentivirus vectors for MOB1A knockdown and overexpression models.
  • Assessed malignant behaviors (proliferation, invasion, migration, cell cycle, autophagy) and PI3K/AKT/mTOR pathway proteins.

Main Results:

  • MOB1A expression was significantly upregulated in OC, correlating with poorer patient survival.
  • Knockdown of MOB1A inhibited OC cell proliferation, invasion, and migration, while inducing autophagy.
  • Conversely, MOB1A upregulation enhanced malignant behaviors; pathway analysis implicated MOB1A in the PI3K/AKT/mTOR signaling.

Conclusions:

  • MOB1A is a key driver in ovarian cancer, exhibiting high expression linked to adverse prognosis.
  • MOB1A promotes tumor cell malignancy through the PI3K/AKT/mTOR signaling pathway, representing a potential therapeutic target.
Keywords:
AutophagyMOB1AOvarian cancerProliferation

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