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MDM2- an indispensable player in tumorigenesis

Aasma Zafar1, Muhammad Jawad Khan1, Aisha Naeem2,3

  • 1Department of Biosciences, COMSATS University, Islamabad, 45550, Pakistan.

Molecular Biology Reports
|June 14, 2023
PubMed

Insights

Murine double minute 2 (MDM2) is an oncogenic molecule driving cancer growth through various cellular processes. Deregulated MDM2 also contributes to therapy resistance, limiting treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Murine double minute 2 (MDM2) is recognized for its oncogenic potential.
  • MDM2 plays established roles in cancer promotion, including growth stimulation, angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression.
  • Altered MDM2 expression levels are observed in numerous cancers, leading to uncontrolled cell proliferation.

Purpose of the Study:

  • To review the precise role of deregulated MDM2 levels in modulating cellular functions that promote cancer growth.
  • To briefly discuss MDM2's role in inducing resistance to anti-cancer therapies.

Main Methods:

  • This is a review article, synthesizing existing research on MDM2.
  • The review discusses MDM2's modulation of cellular processes via transcription, post-translational modifications, protein degradation, cofactor binding, and subcellular localization.

Main Results:

  • MDM2's oncogenic functions are critical for cancer development and progression.
  • Dysregulated MDM2 contributes to uncontrolled cell proliferation and evasion of apoptosis.
  • MDM2 influences key cancer hallmarks like angiogenesis, metabolism, metastasis, and immune suppression.

Conclusions:

  • Deregulated MDM2 is a significant driver of cancer growth by manipulating fundamental cellular processes.
  • MDM2's involvement in therapy resistance poses a challenge for effective cancer treatment.
  • Targeting MDM2 may offer therapeutic strategies for overcoming cancer progression and treatment resistance.
Keywords:
ApoptosisCell signalingMDM2MetabolismTP53

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