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Diagnostic accuracy of the Copenhagen Index in ovarian malignancy: A meta-analysis
Huiling Liu1, Shouye Ma1, Xiaohong Chen1
1Obstetrics and Gynecology Department, Gansu Provincial Hospital, Lanzhou, Gansu, China.
Objective:
To assess the diagnostic value of the Copenhagen index for ovarian malignancy.
Methods:
PubMed, Web of Science, the Cochrane Library, Embase, CBM, CNKI, and WanFang databases were searched throughout June 2021. Statistical analyses were performed using Stata 12, Meta-DiSc, and RevMan 5.3. The pooled sensitivity, specificity, and diagnostic odds ratio were calculated, the summary receiver operating characteristic curve was drawn, and the area under the curve was calculated.
Results:
Ten articles, including 11 studies with a total of 5266 patients, were included. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.82 [95% CI (0.80-0.83)], 0.88 [95% CI (0.87-0.89)], and 57.31 [95% CI (32.84-100.02)], respectively. The area under the summary receiver operating characteristics curve and the Q index were 0.9545 and 0.8966, respectively.
Conclusion:
Our systematic review shows that the sensitivity and specificity of the Copenhagen index are high enough for it to be used in a clinical setting to provide accurate ovarian cancer diagnosis without considering menopausal status.
