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Perception-Action Integration Is Altered in Functional Movement Disorders.

Anne Weissbach1, Josephine Moyé1, Adam Takacs2

  • 1Institute of Systems Motor Science, Center of Brain, Behavior, and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.

Movement Disorders : Official Journal of the Movement Disorder Society
|June 14, 2023
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Summary
This summary is machine-generated.

Patients with functional neurological movement disorders (FMD) show altered perception-action integration, with stronger binding between sensory input and motor output. These neurophysiological abnormalities correlate with symptom severity, highlighting their central role in FMD.

Keywords:
functional movement disorderfunctional neurological disorderperception-action integrationstimulus-responsetheory of event coding

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Area of Science:

  • Neuroscience
  • Movement Disorders
  • Cognitive Science

Background:

  • Functional neurological movement disorders (FMD) primarily present with motor symptoms, but sensory processing deficits are also observed.
  • The precise alterations in perception-action integration, critical for goal-directed behavior, remain unclear in FMD.
  • Understanding these integration processes is key to elucidating FMD pathophysiology.

Purpose of the Study:

  • To investigate perception-action integration in FMD patients at both behavioral and neurophysiological levels.
  • To explore the role of the theory of event coding (TEC) in understanding FMD.

Main Methods:

  • A cohort of 21 FMD patients and 21 controls performed a TEC-related task.
  • Electroencephalogram (EEG) was recorded to capture perception-action integration correlates.
  • Temporal decomposition of EEG data distinguished sensory (S-cluster), motor (R-cluster), and integrated (C-cluster) processing, complemented by source localization.

Main Results:

  • FMD patients exhibited behavioral hyperbinding, indicating difficulty reconfiguring stimulus-response associations.
  • Neuronal activity showed reduced C-cluster modulation in the inferior parietal cortex and altered R-cluster modulation in the inferior frontal gyrus.
  • These neurophysiological alterations correlated significantly with FMD symptom severity.

Conclusions:

  • FMD is characterized by impaired integration of sensory information with motor processes.
  • The observed behavioral and neurophysiological abnormalities in perception-action integration are central to FMD.
  • These findings offer a promising framework for understanding FMD and its clinical manifestations.