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Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series

Ilaria Testi1,2, Camilo Brandão-de-Resende3,4, Alejandra De-La-Torre5

  • 1Department of Uveitis, Moorfields Eye Hospital, NHS Foundation Trust, London, UK.

Ocular Immunology and Inflammation
|June 14, 2023
PubMed

Insights

Ocular inflammatory events, such as uveitis, can occur in children after COVID-19 vaccination. Most cases resolved successfully with treatment, showing good visual outcomes in pediatric patients.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Vaccinology

Background:

  • Ocular inflammatory events have been documented in adults post-COVID-19 vaccination.
  • This study investigates similar events in the pediatric population.

Purpose of the Study:

  • To describe the characteristics and outcomes of ocular inflammatory events in individuals under 18 following COVID-19 vaccination.

Main Methods:

  • A multinational case series was conducted.
  • Included patients under 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 vaccination.

Main Results:

  • Twenty pediatric patients were included. Anterior uveitis was most common (40%), followed by intermediate uveitis (35%).
  • Most events occurred within the first week post-vaccination (55%). Patients received topical/oral corticosteroids or increased immunosuppression.
  • Sixty-five percent of patients achieved complete resolution without complications; all had preserved visual acuity.

Conclusions:

  • COVID-19 vaccination may be associated with ocular inflammatory events in children.
  • These events are generally treatable, with most pediatric patients experiencing favorable visual outcomes.
Abstract

Keywords:
COVID-19ocular inflammationpaediatricuveitisvaccination

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