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Updated: Jul 26, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Curving out a new path: CD28/B7 cis interactions

Xin Ming Matthew Zhou1, Alexander M Mørch1, Michael L Dustin1

  • 1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford, Oxford, UK.

Immunity
|June 14, 2023
PubMed

Important signaling events at the immunological synapse have increasingly been linked to cis interactions between receptors on T cells. In this issue of Immunity, Zhao et al.1 implicate cis CD28/B7 interactions facilitated by curved membrane invaginations in boosting tumor immunity.

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