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Organoid cultures for cancer modeling
Helen H N Yan1, April S Chan1, Frank Pui-Ling Lai1
1Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.
Cell Stem Cell
|June 14, 2023
Summary
Cancer organoid models from adult stem cells (ASCs) and pluripotent stem cells (PSCs) advance preclinical research. These models improve understanding of cancer biology and personalized therapy development.
Area of Science:
- Biomedical research
- Cancer biology
- Stem cell technology
Background:
- Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are valuable preclinical models.
- These models are crucial for cancer research and therapeutic development.
- Understanding cancer requires robust preclinical models that accurately represent human tumors.
Purpose of the Study:
- To review primary tissue-derived and PSC-derived cancer organoid models.
- To explore their potential in personalized medicine and understanding early cancer development.
- To compare ASC- and PSC-based organoid systems and discuss their limitations.
Main Methods:
- Review of existing literature on cancer organoid models.
- Comparative analysis of ASC- and PSC-derived organoid systems.
- Discussion of recent advancements in organoid culture techniques.
Main Results:
- Cancer organoids offer insights into early carcinogenic steps and cancer genomes.
- Both ASC- and PSC-derived organoids have potential for personalized medicine.
- Recent improvements enhance organoid models' representation of human tumors.
Conclusions:
- Cancer organoid models are powerful tools for preclinical cancer research.
- They facilitate the understanding of cancer biology and the development of personalized therapies.
- Ongoing improvements are making organoid systems increasingly accurate representations of human tumors.
