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Related Experiment Video

Updated: Jul 26, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Ultra-high dose-rate proton FLASH improves tumor control.

Samriddhi Shukla1, Taniya Saha1, Nihar Rama1

  • 1Division of Pulmonary Biology, the Perinatal Institute of Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, United States.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|June 14, 2023
PubMed
Summary

Ultrahigh dose-rate proton therapy (FLASH pr) significantly improved tumor control in non-small cell lung cancer (NSCLC) mouse models compared to conventional proton therapy (CONV pr). FLASH pr enhanced anti-tumor immunity and reduced immunosuppression, showing promise for NSCLC treatment.

Keywords:
FLASHLung cancerMouse modelProton radiotherapyUltrahigh dose-rate proton

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Area of Science:

  • Radiation Oncology
  • Immunology
  • Oncology

Background:

  • Proton radiotherapy (PRT) presents advantages over photon and electron radiotherapy.
  • Increasing proton radiation delivery rate may offer therapeutic benefits.

Purpose of the Study:

  • To compare the efficacy of conventional proton therapy (CONV pr) versus ultrahigh dose-rate proton therapy (FLASH pr) in a non-small cell lung cancer (NSCLC) mouse model.

Main Methods:

  • Mice with orthotopic lung tumors underwent thoracic radiation therapy using CONV pr (<0.05 Gy/s) and FLASH pr (>60 Gy/s) dose rates.

Main Results:

  • FLASH pr demonstrated superior tumor burden reduction and decreased tumor cell proliferation compared to CONV pr.
  • FLASH pr increased cytotoxic CD8+ T-lymphocyte infiltration and decreased regulatory T-cells (Tregs).
  • FLASH pr modulated macrophage populations towards an anti-tumor M1 phenotype and reduced immunosuppressive M2 macrophages, while decreasing checkpoint inhibitor expression.

Conclusions:

  • FLASH pr proton delivery enhances anti-tumor immunity and improves tumor control in NSCLC.
  • Ultrahigh dose-rate proton therapy is a promising alternative to conventional dose rates for NSCLC treatment.