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Updated: Jul 26, 2025

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells

Published on: May 17, 2024

Modeling enteric glia development, physiology and disease using human pluripotent stem cells.

Megan D Scantlen¹, Homa Majd², Faranak Fattahi³

¹Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94110, USA.

Neuroscience Letters

|June 14, 2023

Summary

Enteric glia, crucial for gastrointestinal function, are understudied due to experimental challenges. A human pluripotent stem cell model offers a promising solution for advancing enteric glia research.

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Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

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Published on: August 15, 2018

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Last Updated: Jul 26, 2025

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Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Area of Science:

Neuroscience
Gastroenterology
Cell Biology

Background:

Enteric glia are specialized neuroglia in the enteric nervous system (ENS) vital for gastrointestinal (GI) functions.
Despite their abundance and importance, enteric glia remain less understood than enteric neurons due to the difficulty in studying the ENS.
Existing experimental models present limitations for comprehensive enteric glia characterization.

Conclusions:

Advancing enteric glia research is crucial for understanding GI health and disease.
Human pluripotent stem cell technology offers a powerful new avenue for creating specialized enteric glia models.
hPSC-derived enteric glia models hold the potential to unlock new insights into gut physiology and pathology.