Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salivary IgA levels in normal children.

R D'Amelio, R Bonomo, G P D'Offizi

    Diagnostic Immunology
    |January 1, 1986
    PubMed
    Summary

    Salivary IgA (SlgA) levels are often lower in children than adults, with defects present from birth. Full maturation of SlgA occurs after age six, potentially revising its role in immune protection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Green manure can be an auxiliary factor against dynamic photoinhibition in <i>Dalbergia ecastophyllum</i> (L.) young trees in areas impacted by mining.

    Photosynthetica·2025
    Same author

    Urban grey spaces are associated with increased allergy in the general population.

    Environmental research·2021
    Same author

    Clinical and biochemical markers in CIPN: A reappraisal.

    Revue neurologique·2021
    Same author

    Blood molecular biomarkers for chemotherapy-induced peripheral neuropathy: From preclinical models to clinical practice.

    Neuroscience letters·2021
    Same author

    Hypophosphatemia after high-dose iron repletion with ferric carboxymaltose and ferric derisomaltose-the randomized controlled HOMe aFers study.

    BMC medicine·2020
    Same author

    Systemic involvement in adult-onset leukoencephalopathy with intracranial calcifications and cysts (Labrune syndrome) with a novel mutation of the SNORD118 gene.

    European journal of neurology·2020

    Area of Science:

    • Immunology
    • Pediatrics

    Background:

    • Salivary IgA (SlgA) is a crucial immunoglobulin in mucosal immunity.
    • Understanding SlgA development in children is vital for assessing immune competence.

    Purpose of the Study:

    • To determine normal salivary IgA levels in children aged 8 months to 6 years.
    • To identify the prevalence of SlgA defects in this pediatric population.
    • To compare pediatric SlgA levels with adult populations.

    Main Methods:

    • Quantitative analysis of salivary IgA (SlgA) levels.
    • Study cohort: 1,539 healthy children (8 months - 6 years).
    • Comparison with established adult SlgA reference ranges.

    Main Results:

    • Absence of SlgA found in 0.26% of children; relative defects (<1 mg/dl) in 1.62%.

    Related Experiment Videos

  • Mean SlgA levels were significantly lower in all pediatric age groups compared to adults.
  • No significant differences observed between males and females, or correlation with allergic/infectious history.

    • Conclusions:

    • Congenital SlgA defects (absolute or relative) are present from birth.
    • Complete maturation of salivary IgA (SlgA) is achieved after 6 years of age.
    • The protective role of SlgA against allergies and infections may require re-evaluation in early childhood.