Related Experiment Video
Updated: Jul 26, 2025

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
Published on: November 19, 2019
Microbiota Regulates Pancreatic Cancer Carcinogenesis through Altered Immune Response
Yihan Chai1, Zhengze Huang1, Xuqiu Shen1
1Department of General Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
Abstract:
The microbiota is present in many parts of the human body and plays essential roles. The most typical case is the occurrence and development of cancer. Pancreatic cancer (PC), one of the most aggressive and lethal types of cancer, has recently attracted the attention of researchers. Recent research has revealed that the microbiota regulates PC carcinogenesis via an altered immune response. Specifically, the microbiota, in several sites, including the oral cavity, gastrointestinal tract, and pancreatic tissue, along with the numerous small molecules and metabolites it produces, influences cancer progression and treatment by activating oncogenic signaling, enhancing oncogenic metabolic pathways, altering cancer cell proliferation, and triggering chronic inflammation that suppresses tumor immunity. Diagnostics and treatments based on or in combination with the microbiota offer novel insights to improve efficiency compared with existing therapies.
More Related Videos
Related Concept Videos
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Psychoneuroimmunology: Diabetes and Cancer
Tumor Immunotherapy

